Manual Nutrition, Exercise and Epigenetics: Ageing Interventions

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Contents

  1. Recommended for you
  2. 1. Introduction
  3. Figure from Nutrition, Exercise and Epigenetics: Ageing Interventions - Semantic Scholar
  4. Nutrition exercise and epigenetics ageing interventions

Among the genes whose methylation levels were changed significantly by exercise were those involved in metabolism, muscle growth, haematopoeisis and inflammation, with intensity, duration and frequency of exercise important factors. In order to study genomic mechanisms involved in exercise-induced behavioral changes, Kim et al. Chronic restrain stress induced depressive behaviors, immobility and time spent in target zone that were ameliorated by the scheduled forceful exercise intervention.

These behaviors were accompanied by a global reduction of G9a histone methyltransferase and H3K9me2 at the oxytocin and argenine vasopressin promoters; exercise intervention increased the levels of G9a histone methyltransferase and H3K9me2 at the oxytocin and arginine vasopressin promoters in the basolateral amygdala which was linked to suppression of oxytocin and arginine vasopressin expression. In a social defeat-stress resident intruder model of anxiety and depression in rats, Patki et al.

Both social defeat induced anxiety-like behavior, e. Finally, Lindholm et al. These authors obtained consistent and associated modifications, DNA methylation in enhancers, gene bodies and intergenic regions and to a lesser extent in CpG islands or promoters, in methylation and expression, concordant with observed health-enhancing phenotypic adaptations.

Although conclusions concerning exercise effects upon epigenetic modifications are still relatively premature, physical activity-dietary manipulations are being selected may quantify those changes occurring among individuals particularly with immune system inflammaging. Physical exercise offers an epigenetic propensity that holds benefits with several health domains [14 , 15 , 16]. By applying the rat model of acute restraint stress, using Wistar rats, to examine the influence of stress on the global DNA methylation and on the expression of the Dnmt1 and Bdnf genes of hippocampus, cortex, hypothalamus and periaqueductal gray, Rodrigues et al.

They concluded that physical exercise had the potential to modulate changes in DNA methylation and gene expression consequent to stress treatment; a case of a positive epigenetic counteracting a negative one. Utilizing the circumstance of intense endurance running exercise half-marathon to detect global epigenetic modifications in natural killer cells in 14 cancer patients compared to 14 healthy controls, Zimmer et al.

Denham et al. Exercise intensity benefits for positive epigenetic changes in terms of mitochondrial biogenesis were shown by Edgett et al.


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Brown [9] identified imprinted genes in skeletal muscle gene networks and observed exercise-associated DNA methylation alterations. Several CpG island and gene promoter regions were demethylated after exercise, indicating increased genome-wide transcriptional changes, including epidermal growth factor EGF; involved in cardiovascular disease which was demethylated and displayed reduced mRNA expression. The viability of health-promoting epigenetic changes arising from exercise must endower attainable advantages for an aging brain and body. Figure 2. Defining the causal relationship between epigenetic patterns and phenotype.

Figure 3. Applying Mendelian randomization to define the causal relationship between phenotype and disease. Figure 4. Incorporating epigenetic information in a Mendelian randomization framework. Epigenomic Modifiers and the Prospects for Future Treatments It can be argued that mitotically stable changes in gene expression are very likely to underlie the development of virtually all disease in the same way as they are an essential component in the process of the development of an organism [84] , and as definitions of epigenetics incorporate such changes, they automatically fall within the field's remit.

Nat Neurosci 7: — This landmark paper demonstrated that the epigenomic state of a gene can be altered through behavioural programming and that this environmentally induced modification is potentially reversible. This article describes how epigenetic patterns in monozygotic twins become more discordant with advancing age.

This epigenetic drift is postulated to be invoked through differences in environmental exposures. JAMA — Nature — This paper reports the first genome-wide, single base-pair resolution map of methylated cytosines in the mammalian genome from embryonic stem cell and fetal fibroblasts, showing widespread differences between the tissue types. Am J Hum Genet — This study demonstrated that DNA methylation is a heritable trait, determined in part by common genetic variation.

The vast majority of genetically determined variation was observed to be in cis correlation within 1Mb of a CpG site with only a handful of SNPs determining trans methylation distant regulation effects. References 1. New Engl J Med — View Article Google Scholar 2. Bird A Perceptions of epigenetics. View Article Google Scholar 3. Mutat Res 40— View Article Google Scholar 4. View Article Google Scholar 5.

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Hum Mol Genet — View Article Google Scholar 6. J Appl Physiol. Apr 8 [Epub ahead of print]. View Article Google Scholar 7. Meaney MJ Epigenetics and the biological definition of gene x environment interactions. Child Dev 41— View Article Google Scholar 8. Nicholls RD The impact of genomic imprinting for neurobehavioural and developmental disorders. J Clin Invest — View Article Google Scholar 9. Carcinogenesis 27— View Article Google Scholar Nat Rev Cancer 3: — Clin Cancer Res — Trends Genet — Science — Feinberg AP Genome-scale approaches to the epigenetics of common human disease.

Virchows Arch 13— Obes Rev — Epigenetics protocols. Aging Cell. May 22 [Epub ahead of print].

DNA Methylation and Cancer - Garvan Institute

Cell Mol Life Sci — Bollati V, Baccarelli A Environmental epigenetics. Heredity — Haig D Weismann rules! Epigenetics and the Lamarckian temptation. Biol Philos — Ageing Res Rev 8: — Ferguson LR Epigenetic variation and customising nutritional intervention. Curr Pharmacogenomics Person Med 7: — J Nutr Biochem — J Nutr 6 SupplS—S.

1. Introduction

J Appl Genet — Annu Rev Nutr — Myzak MC, Dashwood RH Histone deacetylases as targets for dietary cancer preventive agents: lessons learned with butyrate, diallyl disulfide and sulforaphane. Curr Drug Targets 7: — J Nutr — Cancer Epidemiol Biomarkers Prev — Int J Cancer. E-pub ahead of print. Toxicology 7— Oncogene — Cancer Res — Carcinogenesis — Shaping adult phenotypes through early life environments.

Nutrition, epigenetics, and developmental plasticity: implications for understanding human disease. Annu Rev Nutr. Epigenetics and environment: a complex relationship. J Appl Physiol. Youngson NA, Whitelaw E.


  1. Introduction.
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Transgenerational epigenetic effects. Annu Rev Genomics Hum Genet. Nutri-epigenomics: lifelong remodelling of our epigenomes by nutritional and metabolic factors and beyond. Clin Chem Lab Med. A conceptual framework for the developmental origins of health and disease. J Dev Orig Health Dis. Epigenetic transgenerational actions of endocrine disruptors and male fertility.

Epigenetic transgenerational actions of endocrine disruptors. Environmental epigenomics and disease susceptibility.

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Figure from Nutrition, Exercise and Epigenetics: Ageing Interventions - Semantic Scholar

The maternal and fetal origins of cardiovascular disease. J Epidemiol Community Health. Diet, nutrition and modulation of genomic expression in fetal origins of adult disease.


  • About this book.
  • Epigenetic clock plasticity towards healthy aging;
  • Nutrition, Exercise and Epigenetics: Ageing Interventions | Byung Pal Yu | Springer.
  • Different Seasons.
  • World Rev Nutr Diet. Chmurzynska A. Fetal programming: link between early nutrition, DNA methylation, and complex diseases. Nutr Rev. DNA methylation profiles in monozygotic and dizygotic twins. Petronis A. Epigenetics and twins: three variations on the theme. Epigenetics of discordant monozygotic twins: implications for disease. Genome Med.

    Nutrition exercise and epigenetics ageing interventions

    A sustained dietary change increases epigenetic variation in isogenic mice. The penetrance of an epigenetic trait in mice is progressively yet reversibly increased by selection and environment. Proc Biol Sci. Human transgenerational responses to early-life experience: potential impact on development, health and biomedical research. J Med Genet. Maternal genistein alters coat color and protects Avy mouse offspring from obesity by modifying the fetal epigenome.

    Environ Health Perspect. Environmental epigenomics in human health and disease. Environ Mol Mutagen. Waterland RA.